Microcystin-LR causes cytotoxicity effects in rat testicular Sertoli cells.

  title={Microcystin-LR causes cytotoxicity effects in rat testicular Sertoli cells.},
  author={Yan Li and Xiaodong Han},
  journal={Environmental toxicology and pharmacology},
  volume={33 2},
Microcystins (MCs) are produced by cyanobacteria. The most toxic and widely distributed MC is microcystin-LR (MC-LR). The aim of this study was to investigate whether exposure to MC-LR could induce oxidative stress, leading the further toxicity effects on Sertoli cells in vitro. Sertoli cells obtained from rats were cultured with a medium containing 0, 0.5, 5, 50 or 500 nM/l MC-LR. We examined the decrease of mitochondrial membrane potential (MMP), the increase of reactive oxygen species (ROS… CONTINUE READING


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