Cystic lesions of the pancreas include inflammatory cysts (pseudocysts), congenital cysts and neoplastic cysts. Pseudocysts, which predominate, are identified by having no epithelial lining. Neoplastic cysts represent only 10-15 percent of all pancreatic cysts but must be carefully differentiated from pseudocysts to ensure proper management1-6. Among the different types of cystic neoplasm (Table 1), microcystic adenoma is a benign variant. It is also called serous cystadenoma to distinguish it from the common mucinous cystadenoma, which has a malignant potential. We report two patients with serous cystadenoma of the pancreas, highlighting the use of percutaneous biopsy in its management.