Microculture-based chemosensitivity testing: a feasibility study comparing freshly explanted human melanoma cells with human melanoma cell lines.

@article{Marshall1992MicroculturebasedCT,
  title={Microculture-based chemosensitivity testing: a feasibility study comparing freshly explanted human melanoma cells with human melanoma cell lines.},
  author={Elaine S. Marshall and Graeme Finlay and John H. L. Matthews and John H Shaw and Joe Nixon and B. C. Baguley},
  journal={Journal of the National Cancer Institute},
  year={1992},
  volume={84 5},
  pages={340-5}
}
BACKGROUND The culture of cancer cells has many applications in chemosensitivity testing and new drug development. PURPOSE Our goal was to adapt simple semiautomated microculture methods for testing the chemosensitivity of melanoma cells freshly recovered from patients' tumors. METHODS Cells were cultured on a substrate of agarose and exposed continuously to cytotoxic drugs, the effects of which were measured by determining the uptake of [3H]thymidine 4-7 days later. RESULTS… CONTINUE READING
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