Microcrack frequency and bone remodeling in postmenopausal osteoporotic women on long-term bisphosphonates: a bone biopsy study.

@article{Chapurlat2007MicrocrackFA,
  title={Microcrack frequency and bone remodeling in postmenopausal osteoporotic women on long-term bisphosphonates: a bone biopsy study.},
  author={Roland D. Chapurlat and Monique Arlot and Brigitte Burt-Pichat and Pascale M. Chavassieux and J. P. Roux and Nathalie R. Portero-Muzy and Pierre Dominique Delmas},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2007},
  volume={22 10},
  pages={1502-9}
}
UNLABELLED We sought whether microdamage could rise in postmenopausal osteoporotic women on long-term bisphosphonates, as suggested by recent animal studies. We found few microcracks in iliac bone biopsies, despite a marked reduction in bone turnover. INTRODUCTION Animal studies suggest that bisphosphonates (BPs) could increase microdamage frequency in a dose-dependent manner, caused by excessively suppressed bone turnover. However, there is limited data in humans receiving BP therapeutic… CONTINUE READING
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