Microcirculatory pathways and blood flow in spleen: new insights from washout kinetics, corrosion casts, and quantitative intravital videomicroscopy.

@article{Groom1991MicrocirculatoryPA,
  title={Microcirculatory pathways and blood flow in spleen: new insights from washout kinetics, corrosion casts, and quantitative intravital videomicroscopy.},
  author={A C Groom and Eric E. Schmidt and I C Macdonald},
  journal={Scanning microscopy},
  year={1991},
  volume={5 1},
  pages={159-73; discussion 173-4}
}
The dynamics of splenic microcirculatory blood flow and the role of the spleen with respect to red blood cells (RBCs) have been elucidated by means of several different experimental approaches. First, the organ was treated as a 'black box' and input/output relationships were studied, such as the kinetics of RBC and plasma washout during Ringer perfusion. Second, microcorrosion casts were prepared from minimal amounts of injected material, such that 'fast' pathways for flow were selectively… CONTINUE READING

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