Microcircuits and their interactions in epilepsy: is the focus out of focus?

@article{Paz2015MicrocircuitsAT,
  title={Microcircuits and their interactions in epilepsy: is the focus out of focus?},
  author={Jeanne T Paz and John R. Huguenard},
  journal={Nature Neuroscience},
  year={2015},
  volume={18},
  pages={351-359}
}
Epileptic seizures represent dysfunctional neural networks dominated by excessive and/or hypersynchronous activity. Recent progress in the field has outlined two concepts regarding mechanisms of seizure generation, or ictogenesis. First, all seizures, even those associated with what have historically been thought of as 'primary generalized' epilepsies, appear to originate in local microcircuits and then propagate from that initial ictogenic zone. Second, seizures propagate through cerebral… CONTINUE READING
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