Microcin C and albomycin analogues with aryl-tetrazole substituents as nucleobase isosters are selective inhibitors of bacterial aminoacyl tRNA synthetases but lack efficient uptake.

Abstract

In 1998, Cubist Pharmaceuticals patented a series of aminoacyl tRNA synthetase (aaRS) inhibitors based on aminoacyl sulfamoyladenosines (aaSAs), in which the adenine was substituted by aryl-tetrazole moieties linked to the ribose fragment by a two-carbon spacer. Although potent and specific inhibitors of bacterial IleRS, these compounds did not prove… (More)
DOI: 10.1002/cbic.201200174

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Cite this paper

@article{Vondenhoff2012MicrocinCA, title={Microcin C and albomycin analogues with aryl-tetrazole substituents as nucleobase isosters are selective inhibitors of bacterial aminoacyl tRNA synthetases but lack efficient uptake.}, author={Gaston H M Vondenhoff and Bharat Gadakh and Konstantin Severinov and Arthur van Aerschot}, journal={Chembiochem : a European journal of chemical biology}, year={2012}, volume={13 13}, pages={1959-69} }