Microcin C: biosynthesis, mode of action, and potential as a lead in antibiotics development.

Abstract

The natural compound Microcin C (McC) is a Trojan horse inhibitor of aspartyl tRNA synthetases endowed with strong antibacterial properties, in which a heptapeptide moiety is responsible for active transport of the inhibitory metabolite part into the bacterial cell. The intracellularly formed aspartyl AMP analogue carries a chemically more stable… (More)
DOI: 10.1080/15257770.2011.583972

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Cite this paper

@article{Vondenhoff2011MicrocinCB, title={Microcin C: biosynthesis, mode of action, and potential as a lead in antibiotics development.}, author={Gaston H M Vondenhoff and Arthur van Aerschot}, journal={Nucleosides, nucleotides & nucleic acids}, year={2011}, volume={30 7-8}, pages={465-74} }