Microchip-based ultrafast serodiagnostic assay for tuberculosis

@article{Mani2016MicrochipbasedUS,
  title={Microchip-based ultrafast serodiagnostic assay for tuberculosis},
  author={Vigneshwaran Mani and Bhairav Suryakant Paleja and Karima Larbi and Pavanish Kumar and Jo Ann Tay and Jie Yee Siew and Fatih Inci and Shuqi Wang and Cynthia B E Chee and Yee-Tang Wang and Utkan Demirci and Gennaro De Libero and Amit Singhal},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Access to point-of-care (POC), rapid, inexpensive, sensitive, and instrument-free tests for the diagnosis of tuberculosis (TB) remains a major challenge. Here, we report a simple and low-cost microchip-based TB ELISA (MTBE) platform for the detection of anti-mycobacterial IgG in plasma samples in less than 15 minutes. The MTBE employs a flow-less, magnet-actuated, bead-based ELISA for simultaneous detection of IgG responses against multiple mycobacterial antigens. Anti-trehalose 6,6′-dimycolate… 

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