Microchimerism, GVHD, and tolerance in solid organ transplantation.

@article{Triulzi2001MicrochimerismGA,
  title={Microchimerism, GVHD, and tolerance in solid organ transplantation.},
  author={Darrell J. Triulzi and Michael Andrew Nalesnik},
  journal={Transfusion},
  year={2001},
  volume={41 3},
  pages={419-26}
}
The phenomenon of microchimerism and its relationship to long-term graft tolerance is an area of active study. The ability to establish a tolerant state has been enhanced with current immunosuppressive drugs and emerging therapies such as donor HPC infusions. An undesirable outcome of host-donor WBC interaction is GVHD. GVHD is a rare complication reported most frequently in liver transplantation. Two cases of GVHD reported in recipients of organs from donors homozygous for a shared HLA… CONTINUE READING

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