Microchannels created by sugar and metal microneedles: characterization by microscopy, macromolecular flux and other techniques.

@article{Li2010MicrochannelsCB,
  title={Microchannels created by sugar and metal microneedles: characterization by microscopy, macromolecular flux and other techniques.},
  author={Guohua Li and Advait V. Badkar and Haripriya Kalluri and Ajay K. Banga},
  journal={Journal of pharmaceutical sciences},
  year={2010},
  volume={99 4},
  pages={1931-41}
}
The objective of this study was to investigate the feasibility of using microneedle technology to enhance transcutaneous permeation of human immunoglobulin G (IgG) across hairless rat skin. Microchannels created by maltose and metal (DermaRoller) microneedles were characterized by techniques such as methylene blue staining, histological examination, and calcein imaging. Methylene blue staining and histological sections of treated skin showed that maltose microneedles and DermaRoller breached… CONTINUE READING

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