Microchannel Technologies for Artificial Lungs: (1) Theory

@article{Lee2008MicrochannelTF,
  title={Microchannel Technologies for Artificial Lungs: (1) Theory},
  author={J. K. Lee and H. Kung and L. Mockros},
  journal={ASAIO Journal},
  year={2008},
  volume={54},
  pages={372-382}
}
The feasibility of developing micro channel artificial lungs is calculated for eight possible strategies: 12 and 25 &mgr;m circular channels imbedded in gas-permeable sheets, 12 and 25 &mgr;m high open rectangular channels with gas-permeable walls, 12 and 25 &mgr;m high broad open channels with support posts and gas-permeable walls, and two 40 &mgr;m high screen-filled rectangular channels with gas-permeable walls. Each strategy is considered by imposing a pressure drop maximum of 10 mm Hg and… Expand
Microchannel Technologies for Artificial Lungs: (2) Screen-filled Wide Rectangular Channels
TLDR
The present work explores the effectiveness of 40 &mgr;m screen-filled blood-side channels and, as a comparison, 82 screen- filled channels and suggests a required blood prime of only 35 ml is needed for microchannel artificial lungs. Expand
Microchannel Technologies for Artificial Lungs: (3) Open Rectangular Channels
TLDR
Lithographic techniques were used to develop patterned silicone rubber membranes that provide 15 &mgr;m high microchannels for artificial lungs that can be arbitrarily wide and would be less prone to blockage. Expand
The promise of microfluidic artificial lungs.
  • J. Potkay
  • Engineering, Medicine
  • Lab on a chip
  • 2014
TLDR
This manuscript reviews recent research efforts in microfluidic artificial lungs, investigates the ultimate performance and scaling limits of these devices using a proven mathematical model, and discusses the future challenges that must be overcome in order for these devices to be applied in the clinic. Expand
A microfluidic respiratory assist device with high gas permeance for artificial lung applications
TLDR
The design, fabrication and initial testing of a parallel plate multilayered silicone-based microfluidic construct containing ultrathin gas exchange membranes, aimed at maximizing gas transfer efficiency while minimizing membrane-blood contact area are reported. Expand
Ultra-thin, gas permeable free-standing and composite membranes for microfluidic lung assist devices.
Membranes for a lung assist device must permit the exchange of gaseous O₂ and CO₂ while simultaneously acting as a liquid barrier, so as to prevent leakage of blood and its components from passingExpand
A small-scale, rolled-membrane microfluidic artificial lung designed towards future large area manufacturing.
TLDR
This work presents a new manufacturing technology for a microfluidic artificial lung in which the structure is assembled via a continuous "rolling" and bonding procedure from a single, patterned layer of polydimethyl siloxane (PDMS). Expand
A simple, closed-form, mathematical model for gas exchange in microchannel artificial lungs
  • J. Potkay
  • Engineering, Medicine
  • Biomedical microdevices
  • 2013
TLDR
This work describes a simple, closed-form mathematical model for gas exchange in microchannel artificial lungs and qualifies it through application to experimental data from several research groups, utilizing lumped parameters and several assumptions to obtain a closed- form set of equations that describe gas exchange. Expand
Lung assist device: development of microfluidic oxygenators for preterm infants with respiratory failure.
TLDR
The main focus of this paper is the presentation of the development of the MFO units testing various membrane materials with human blood to enhance gas exchange and in the design of fluidic inlets to lower the pressure drop across the oxygenator. Expand
Influence of Vascular Network Design on Gas Transfer in Lung Assist Device Technology
TLDR
These relationships can be used to optimize future biomimetic vascular networks for specific lung applications: gas transfer for carbon dioxide removal in patients with chronic obstructive pulmonary disease or oxygenation for premature infants requiring complete lung replacement therapy. Expand
Novel scalable and monolithically integrated extracorporeal gas exchange device
TLDR
The EGED allows for double sided gas exchange and enables an adaption to the diversity of medical requirements by scaling the amount of layers, and the linear scalability of the concept as well as the functionality of the EGED with air as ventilation gas is shown. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 14 REFERENCES
Microchannel Technologies for Artificial Lungs: (2) Screen-filled Wide Rectangular Channels
TLDR
The present work explores the effectiveness of 40 &mgr;m screen-filled blood-side channels and, as a comparison, 82 screen- filled channels and suggests a required blood prime of only 35 ml is needed for microchannel artificial lungs. Expand
Microchannel Technologies for Artificial Lungs: (3) Open Rectangular Channels
TLDR
Lithographic techniques were used to develop patterned silicone rubber membranes that provide 15 &mgr;m high microchannels for artificial lungs that can be arbitrarily wide and would be less prone to blockage. Expand
Slow viscous flow in a lung alveoli model.
  • J. Lee
  • Engineering, Medicine
  • Journal of biomechanics
  • 1969
TLDR
An approximate solution which gives a reasonable representation for flow around a circular post confined between two plates, is extended to construct a periodic solution for the present problem and results are shown to agree substantially with experimental measurements of the resistance. Expand
Oxygen Transport in 10μM Artificial Capillaries
In order to further define the influence of microvessel diameter on intraluminal oxygen transport a previously described in vitro artificial capillary system was modified from a vessel diameter of 25Expand
Simulation of intraluminal gas transport processes in the microcirculation
TLDR
The background for the long period of misdirection, and progress in placing the simulation of gas transport processes on a more accurate, quantitative basis are reviewed. Expand
Experimental Simulation of Oxygen Transport in Microvessels
Experimental and mathematical methods of simulating microcirculatory oxygen transport to tissue have been of interest since the early work of Krogh (1919, 1922). Development of reliable simulationExpand
Engineering design of thoracic artificial lungs
  • The Artificial Lung
  • 2002
Engineering design of thoracic artificial lungs , in Vaslef SN , Anderson RW ( eds ) , The Artificial Lung
  • 2002
KE: Engineering design of thoracic artificial lungs, in Vaslef SN, Anderson RW (eds), The Artificial Lung
  • Tissue Engineering Intelligence Unit
  • 2002
Biodynamics Circulation
  • 1984
...
1
2
...