Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex.

  title={Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex.},
  author={Dan Xu and Feng Zhang and Yaqing Wang and Yiming Sun and Zhiheng Xu},
  journal={Cell reports},
  volume={6 6},
The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development
A timely review of current understanding of WDR62 contributions in the self-renewal, expansion and fate specification of neural stem and progenitor cells that are critical for neocortical development and recently elaborated WDR 62 interaction partners that include Aurora and c-Jun N-terminal kinases are discussed.
WDR62 regulates mouse oocyte meiotic maturation related to p-JNK and H3K9 trimethylation.
Neurological outcome in WDR62 primary microcephaly
To characterize the cortical structure, developmental, and cognitive profiles of patients with WD repeat domain 62 (WDR62)‐related primary microcephaly, a large number of patients are diagnosed with atypical cortical structure and developmental problems.
WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis
It is found that WDR62 deficiency leads to centriole underduplication in the spermatocytes due to reduced or delayed CEP63 accumulation in the pericentriolar matrix, which resulted in prolonged metaphase that led to apoptosis.
Putative Cellular and Molecular Roles of Zika Virus in Fetal and Pediatric Neuropathologies
  • Rajendra Gharbaran, L. Somenarain
  • Biology, Medicine
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2019
This review highlights the cellular and molecular evidence that implicate ZIKV in fetal and pediatric neuropathologies and the mechanisms by which it produces it suspected pathophysiological effects are not completely understood.
WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis
It is found that the initiation of meiosis following spermatogenesis was not affected and the germ cells were gradually repopulated at later developmental stages, and this study demonstrated a new function of WDR62 in germ cell meiosis, through its interaction with CEP170.
Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin
Data implicate that HIRA, cooperating with Setd1A, modulates &bgr;-catenin expression and then regulates neurogenesis, which represents a novel epigenetic mechanism underlying the histone code and has profound and lasting implications for diseases and neurobiology.