Microcephaly: general considerations and aids to nosology.
@article{Opitz1990MicrocephalyGC, title={Microcephaly: general considerations and aids to nosology.}, author={J. Opitz and M. Holt}, journal={Journal of craniofacial genetics and developmental biology}, year={1990}, volume={10 2}, pages={ 175-204 } }
Microcephaly is defined as an occipito-frontal head circumference (OFC) 2 or more standard deviations below the mean for age and sex using the new Roche et al. [Pediatrics 1987;79:706-712] charts, and corrected for parental OFC by the method of Weaver and Christian [J Pediatr 1980;96:990-994]. "Relative" microcephaly, i.e., a small head on a small child, may be associated with a much better intellectual prognosis than absolute microcephaly, although the average IQ of children with absolute… CONTINUE READING
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