• Biology, Medicine
• Published in
  Journal of craniofacial…
  1990

Microcephaly: general considerations and aids to nosology.

@article{Opitz1990MicrocephalyGC,
  title={Microcephaly: general considerations and aids to nosology.},
  author={John M Opitz and Mandy Holt},
  journal={Journal of craniofacial genetics and developmental biology},
  year={1990},
  volume={10 2},
  pages={
          175-204
        }
}

• John M Opitz, Mandy Holt

Microcephaly is defined as an occipito-frontal head circumference (OFC) 2 or more standard deviations below the mean for age and sex using the new Roche et al. [Pediatrics 1987;79:706-712] charts, and corrected for parental OFC by the method of Weaver and Christian [J Pediatr 1980;96:990-994]. "Relative" microcephaly, i.e., a small head on a small child, may be associated with a much better intellectual prognosis than absolute microcephaly, although the average IQ of children with absolute… CONTINUE READING

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