Microcephaly: STIL(l) a Tale of Too Many Centrosomes

@article{Marthiens2014MicrocephalySA,
  title={Microcephaly: STIL(l) a Tale of Too Many Centrosomes},
  author={V{\'e}ronique Marthiens and Renata Basto},
  journal={Current Biology},
  year={2014},
  volume={24},
  pages={R162-R164}
}
Centrosome mutations associated with microcephaly are normally thought to result in loss-of-function phenotypes. A new study shows, however, that mutations found in the human microcephaly STIL gene cause centrosome amplification, suggesting a direct link between the presence of extra centrosomes and the establishment of this disease.