Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans

@article{Evans2005MicrocephalinAG,
  title={Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans},
  author={P. Evans and S. L. Gilbert and N. Mekel-Bobrov and E. Vallender and Jeffrey R. Anderson and Leila M. Vaez-Azizi and S. Tishkoff and R. Hudson and B. Lahn},
  journal={Science},
  year={2005},
  volume={309},
  pages={1717 - 1720}
}
The gene Microcephalin (MCPH1) regulates brain size and has evolved under strong positive selection in the human evolutionary lineage. We show that one genetic variant of Microcephalin in modern humans, which arose ∼37,000 years ago, increased in frequency too rapidly to be compatible with neutral drift. This indicates that it has spread under strong positive selection, although the exact nature of the selection is unknown. The finding that an important brain gene has continued to evolve… Expand
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Normal variants of Microcephalin and ASPM do not account for brain size variability.
MCPH , a disorder of neurogenic mitosis affecting foetal brain growth
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