Microbiota organization is a distinct feature of proximal colorectal cancers.

  title={Microbiota organization is a distinct feature of proximal colorectal cancers.},
  author={Christine M. Dejea and Elizabeth C. Wick and Elizabeth M. Hechenbleikner and James Robert White and Jessica L Mark Welch and Blair J. Rossetti and Scott N. Peterson and Erik C. Snesrud and Gary G. Borisy and Mark G. Lazarev and Ellen Stein and Jamuna Vadivelu and April C Roslani and Ausuma A Malik and Jane W Wanyiri and Khean Lee Goh and Iyadorai Thevambiga and Kai Fu and Fengyi Wan and Nicolas J. Llosa and Franck Housseau and Katharine E. Romans and Xinqun Wu and F McAllister and Shaoguang Wu and Bert Vogelstein and Kenneth W. Kinzler and Drew Mark Pardoll and Cynthia L Sears},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 51},
Environmental factors clearly affect colorectal cancer (CRC) incidence, but the mechanisms through which these factors function are unknown. One prime candidate is an altered colonic microbiota. Here we show that the mucosal microbiota organization is a critical factor associated with a subset of CRC. We identified invasive polymicrobial bacterial biofilms (bacterial aggregates), structures previously associated with nonmalignant intestinal pathology, nearly universally (89%) on right-sided… CONTINUE READING
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