Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism.

@article{Cheng2014MicrobiotaMT,
  title={Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism.},
  author={Min Cheng and Liting Qian and Guodong Shen and Geng Bian and Tingjuan Xu and Weiping Xu and Gan Shen and Shilian Hu},
  journal={Cancer research},
  year={2014},
  volume={74 15},
  pages={4030-41}
}
Commensal bacteria are crucial to maintain immune homeostasis in mucosal tissues and disturbances in their ecology can affect disease susceptibility. Here, we report evidence that commensal bacteria shape the efficiency of immune surveillance in mucosal tissues. Antibiotic-treated (Abt) mice were more susceptible to development of engrafted B16/F10 melanoma and Lewis lung carcinoma, exhibiting a shortened mean survival time with more numerous and larger tumor foci in the lungs. The defective… CONTINUE READING