Microbiota in autoimmunity and tolerance.

  title={Microbiota in autoimmunity and tolerance.},
  author={Koji Atarashi and Kenya Honda},
  journal={Current opinion in immunology},
  volume={23 6},
The composition of a host's intestinal microbiota directs the type of mucosal and systemic immune responses by affecting the proportion and number of functionally distinct T cell subsets. In particular, the microbiota composition affects the differentiation of intestinal Th17 cells and Foxp3(+) regulatory T cells, both of which play critical roles in maintaining mucosal barrier functions and in controlling immunological homeostasis. In this review, we discuss the recent advances in our… CONTINUE READING
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