Microbiota and host determinants of behavioural phenotype in maternally separated mice.

@article{Palma2015MicrobiotaAH,
  title={Microbiota and host determinants of behavioural phenotype in maternally separated mice.},
  author={Giada De Palma and Patricia A Blennerhassett and Jun Lu and Yikang Deng and Amber J. Park and W Green and Emmanuel Denou and Marcio A. Silva and Arlette Santacruz and Yolanda Echegoyen Sanz and Michael G. Surette and Elena F. Verd{\'u} and Stephen M. Collins and Premysl Bercik},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={7735}
}
Early-life stress is a determinant of vulnerability to a variety of disorders that include dysfunction of the brain and gut. Here we exploit a model of early-life stress, maternal separation (MS) in mice, to investigate the role of the intestinal microbiota in the development of impaired gut function and altered behaviour later in life. Using germ-free and specific pathogen-free mice, we demonstrate that MS alters the hypothalamic-pituitary-adrenal axis and colonic cholinergic neural regulation… CONTINUE READING

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