Microbiota and colorectal cancer: colibactin makes its mark

  title={Microbiota and colorectal cancer: colibactin makes its mark},
  author={Janelle C. Arthur},
  journal={Nature Reviews Gastroenterology \& Hepatology},
  • J. Arthur
  • Published 21 April 2020
  • Medicine
  • Nature Reviews Gastroenterology & Hepatology
Colibactin-producing bacteria are abundant in the gut microbiota of colorectal cancer tumours and promote colon tumorigenesis in mouse models. Now, a new study demonstrates a direct link between exposure of human intestinal epithelial cells to colibactin and two unique mutational fingerprints found in human colorectal tumours. 
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