Microbiota and Its Role in Metabolism of Common Drugs – A Short Review

@inproceedings{Jamwal2015MicrobiotaAI,
  title={Microbiota and Its Role in Metabolism of Common Drugs – A Short Review},
  author={Rohitash Jamwal and Sumanta K Goswami},
  year={2015}
}
Our gut is home to over a trillion of microbes existing in a symbiotic relationship with its host organ. The enzymes synthesized by gut Microflora have been long known to influence our health, but their role in the metabolism of drugs has not been studied to that extent. Similar to drug metabolizing enzymes in liver and intestine, gut Microbiota can modulate the metabolism of drugs in a number of ways including but not limited to hydrolysis, reduction, or degradation of a drug molecule. The… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.

  • Drug metabolism and disposition: the biological fate of chemicals
  • 1997
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

The treatment of early Parkinson’s disease: levodopa rehabilitated

A Vlaar, A Hovestadt, T Van laar, BR. Bloem
  • Pract Neurol
  • 2011

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007
VIEW 1 EXCERPT