Microbiota alterations in proline metabolism impact depression.

@article{MaynerisPerxachs2022MicrobiotaAI,
  title={Microbiota alterations in proline metabolism impact depression.},
  author={Jordi Mayneris‐Perxachs and Anna Castells-Nobau and Mar{\'i}a Arnoriaga-Rodr{\'i}guez and Miquel Martin and Lisset de la Vega-Correa and Cristina Zapata and Aurelijus Burokas and Gerard Blasco and Cl{\`a}udia Coll and Anira Escrichs and Carles Biarnes and Jos{\'e} Mar{\'i}a Moreno-Navarrete and Josep Puig and Josep Garre-Olmo and Rafel Ramos and Salvador Pedraza and Ramon Brugada and Joan Carles Vilanova and Joaqu{\'i}n Serena and Jordi Gich and Llu{\'i}s Rami{\'o}-Torrent{\'a} and Vicente P{\'e}rez-Brocal and Andr{\'e}s Moya and R. Pamplona and Joaquim Sol and Mariona Jov{\'e} and Wifredo Ricart and Manuel Portero-Ot{\'i}n and Gustavo Deco and Rafael Maldonado and Jos{\'e} Manuel Fern{\'a}ndez-Real},
  journal={Cell metabolism},
  year={2022},
  volume={34 5},
  pages={
          681-701.e10
        }
}

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References

SHOWING 1-10 OF 97 REFERENCES

Recognizing Depression from the Microbiota–Gut–Brain Axis

Depression is closely related with the health condition of the brain–gut axis, and maintaining/restoring the normal condition of gut microbiota helps in the prevention/therapy of mental disorders.

The Microbiota-Gut-Brain Axis.

Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.

The neuroactive potential of the human gut microbiota in quality of life and depression

Correlation of microbiome features with host quality of life and depression identified specific taxa and microbial pathways in two independent, large population cohorts, identifying links between microbial neuroactive potential and depression.

The gut microbiota in anxiety and depression - A systematic review.

Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts, highlighting the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts.

Neurotransmitter modulation by the gut microbiota

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

It is hypothesised that anxiety and depressive disorders are linked to human gut dysbiosis with microbiota that secrete lipopolysaccharide endotoxin into plasma, which in conjunction with compromised gut barrier integrity has systemic manifestations including the brain.

Behavioral and neurochemical effects of proline

This review addresses some of the findings obtained, mainly from animal studies, indicating that high proline levels may be associated to neuropathophysiology of some disorders, and offers new perspectives for potential therapeutic strategies for this condition.
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