Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis.

@article{Vadder2016MicrobiotaProducedSI,
  title={Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis.},
  author={Filipe de Vadder and Petia Kovatcheva-Datchary and Carine Zitoun and Adeline Duchampt and Fredrik B{\"a}ckhed and Gilles Mithieux},
  journal={Cell metabolism},
  year={2016},
  volume={24 1},
  pages={
          151-7
        }
}
Beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. However, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. Here, we fed mice a fiber-rich diet and found that succinate was the most abundant carboxylic acid in the cecum. Dietary succinate was… CONTINUE READING

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