Microbiota Modulates Behavior and Protein Kinase C mediated cAMP response element-binding protein Signaling

  title={Microbiota Modulates Behavior and Protein Kinase C mediated cAMP response element-binding protein Signaling},
  author={Li Zeng and Benhua Zeng and Haiyang Wang and Bo Li and Ran Huo and Peng Zheng and Xiaotong Zhang and Xiangyu Du and Meiling Liu and Zheng Fang and Xue-jiao Xu and Chanjuan Zhou and Jian-jun Chen and Wenxia Li and J{\`i}ng Guo and Hong Wei and Peng Xie},
  journal={Scientific Reports},
Evolutionary pressure drives gut microbiota–host coevolution and results in complex interactions between gut microbiota and neural development; however, the molecular mechanisms by which the microbiota governs host behavior remain obscure. Here, we report that colonization early in life is crucial for the microbiota to modulate brain development and behavior; later colonization or deletion of microbiota cannot completely reverse the behaviors. Microarray analysis revealed an association between… 

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