Microbiota: Dysbiosis driven by inflammasome deficiency exacerbates hepatic steatosis and governs rate of NAFLD progression

  title={Microbiota: Dysbiosis driven by inflammasome deficiency exacerbates hepatic steatosis and governs rate of NAFLD progression},
  author={Natalie J. Wood},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  • Natalie J. Wood
  • Published 21 February 2012
  • Medicine, Biology
  • Nature Reviews Gastroenterology &Hepatology
Microbiota: Dysbiosis driven by inflammasome deficiency exacerbates hepatic steatosis and governs rate of NAFLD progression 

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Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Altered interactions between the gut microbiota and the host, produced by defective NLRP3 and NLRP6 inflammasome sensing, may govern the rate of progression of multiple metabolic syndrome-associated abnormalities, highlighting the central role of the microbiota in the pathogenesis of heretofore seemingly unrelated systemic auto-inflammatory and metabolic disorders.