Microbiota, Epithelium, Inflammation, and TGF-β Signaling: An Intricate Interaction in Oncogenesis

  title={Microbiota, Epithelium, Inflammation, and TGF-$\beta$ Signaling: An Intricate Interaction in Oncogenesis},
  author={Xin Pang and Ya-Jie Tang and Xiao-hua Ren and Qian Chen and Ya-Ling Tang and Xin-hua Liang},
  journal={Frontiers in Microbiology},
Microbiota has been widely considered to play a critical role in human carcinogenesis. Recent evidence demonstrated that microbiota, epithelial barrier and inflammation has made up a tightly interdependent triangle during the process of carcinogenesis. Hence, we discussed the triangle relationship of microbiota dysbiosis, epithelial barrier dysfunction and dysregulated immune responses to elucidate the mechanisms by which microbiota induces carcinogenesis, especially highlighting the reciprocal… 

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