Microbioreactor Arrays for Full Factorial Screening of Exogenous and Paracrine Factors in Human Embryonic Stem Cell Differentiation

Abstract

Timed exposure of pluripotent stem cell cultures to exogenous molecules is widely used to drive differentiation towards desired cell lineages. However, screening differentiation conditions in conventional static cultures can become impractical in large parameter spaces, and is intrinsically limited by poor spatiotemporal control of the microenvironment that… (More)
DOI: 10.1371/journal.pone.0052405

Topics

4 Figures and Tables

Cite this paper

@inproceedings{Titmarsh2012MicrobioreactorAF, title={Microbioreactor Arrays for Full Factorial Screening of Exogenous and Paracrine Factors in Human Embryonic Stem Cell Differentiation}, author={Drew M. Titmarsh and James E Hudson and Alejandro Hidalgo and Andrew G. Elefanty and Edouard G. Stanley and Ernst J Wolvetang and Justin J. Cooper-White}, booktitle={PloS one}, year={2012} }