Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.

@article{Li2013MicrobiomeRL,
  title={Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.},
  author={Fei Li and Changtao Jiang and Kristopher W. Krausz and Yunfei Li and Istv{\'a}n Albert and Haiping Hao and Kristin M. Fabre and James B. Mitchell and Andrew D. Patterson and Frank J. Gonzalez},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={
          2384
        }
}
The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut microbiome by preferentially reducing the genus Lactobacillus and its bile salt hydrolase (BSH) activity leading to the accumulation of intestinal tauro-β-muricholic acid (T-β-MCA). T-β-MCA is an farnesoid X receptor (FXR) nuclear receptor antagonist, which is involved in the regulation of bile acid, lipid and glucose metabolism. Its increased levels during tempol treatment inhibit FXR signalling in the… CONTINUE READING
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a study expanding tempol pharmacology

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