Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity.

@article{Brusca2014MicrobiomeAM,
  title={Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity.},
  author={Samuel B. Brusca and Steven B. Abramson and Jose U. Scher},
  journal={Current opinion in rheumatology},
  year={2014},
  volume={26 1},
  pages={101-7}
}
PURPOSE OF REVIEW Despite the progress toward understanding the molecular pathogenesis of rheumatoid arthritis (RA), its cause remains elusive. Genes are important but rather insufficient to explain the majority of RA cases. This review describes the novel data supporting the microbiome and its interactions with the human host as potential en('in')vironmental factors in RA pathogenesis. RECENT FINDINGS Animal models of inflammatory arthritis have shown that the presence of bacteria in mucosal… CONTINUE READING
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