Microbiological stability of tablets stored under tropical conditions

@article{Bos1989MicrobiologicalSO,
  title={Microbiological stability of tablets stored under tropical conditions},
  author={C. E. Bos and Hans van Doorne and Coenraad F. Lerk},
  journal={International Journal of Pharmaceutics},
  year={1989},
  volume={55},
  pages={175-183}
}
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25 Citations
Highly Influential Citations
2
Background Citations
6
Results Citations
1

25 Citations

Effect of Some Storage Conditions upon the Survival of Some Fungal Spores
Folic acid and multivitamin tablets containing Aspergillus flavus Penicillia spp. and Cladosporia spores were prepared at a compression pressure of 148 MN/m 2 and stored at 35°C under different…
Optimization of Tablet Formulations Based on Starch/Lactose Granulations for Use in Tropical Countries
AbstractSeveral granulations consisting of α-lactose monohydrate 200 mesh and native starch (corn, potato, rice or tapioca) were prepared. The influence of starch concentration, storage temperature…
INTERRELATIONS OF DRYING HEAT AND SURVIVAL OF DIFFERENT FUNGAL SPORES WITHIN THE TABLETS FORMULATION
TLDR
The results showed that the drying heat caused the inactivation of about 32% of Aspergillus flavus spores and 36.6 % of Penicillium spp.
Microbiological quality of spray dried pharmaceutical plant extracts
Effect of compression pressure, preservative, and storage with potassium chloride on the microbiological quality of tablets formulated with Terminalia randii Gum (Combretaceae).
TLDR
Studies showed that compression pressures and duration of storage caused marked reduction in microbial load of the tablets formulated with the processed gum of Terminalia randii as a binder.
Microbial contamination and preservative capacity of some brands of cosmetic creams
TLDR
Commercial cosmetic creams and lotions evaluated did not generally meet the standards for microbial limits as specified in official monographs, which can adversely affect health status of consumers as well as the stability profiles of the products.
Surface Microbial Contamination in Some Commonly Available Tablet Dosage Forms
TLDR
Commonly available nonprescription drugs in tablet dosage form have been shown to be frequently contaminated by microorganisms, however, cases of microscopic visualization of microbial contamination of drugs do not often result in recoverable cultures on growth media.
Microbiological Evaluation of Ten Commercial Cough Syrups during Storage
TLDR
The cough syrups evaluated did not generally meet the standards for microbial limit as specified in official monographs and can adversely affect health status of consumers, hence, the need for regular quality control and assurance.
Compressibility and Dissolution Characteristics of Mixed Fruit Tablets Made from Guava and Pitaya Fruit Powders.
Microbiological evaluation of cosmetics products sourced in Aba city, Nigeria
TLDR
The poor microbiological quality of the preparations investigated can be attributed to either the formulation of these brands or environmental conditions during the manufacturing process and it is hoped that the training of the personnel that handle these processes will improve cosmetic products quality in Nigeria.
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References

SHOWING 1-10 OF 10 REFERENCES
Effect of spatial distribution of contaminant microorganisms within tablet formulations on subsequent inactivation through compaction
Enumeration of Bacillus cereus in foods.
For the enumeration of vegetative cells and spores of Bacillus cereus in foods, a mannitol-egg yolk-phenol red-agar has been developed which exploits the failure of B. cereus to dissimilate mannitol,…
Survival of Staphylococcus aureus on pharmaceutical oral solid dosage forms.
TLDR
The relationship of temperature, relative humidity, size of inoculum, and duration of storage on survival of Staphylococcus aureus inoculated onto surfaces of 17 commercial tablets and one gelatin capsule was determined and storage environment appeared to be the most significant.
Inimical effects of compaction speed on microorganisms in powder systems with dissimilar compaction mechanisms.
TLDR
Scanning electron micrographs of fractured compacts revealed that particle rearrangement, fragmentation, and deformation significantly influence the "survivor" in brittle material.
Stability Testing in Industry for Worldwide Marketing
TLDR
The aim is to describe, from Industry's point of view, what outlay is necessary for stability Testing for worldwide marketing and what degree of confidence lies behind the stability predictions.
Degradation mechanisms for water-soluble drugs in solid dosage forms.
TLDR
Thiamine hydrochloride, when tableled with magnesium stearate and microcrystalline cellulose, degrades in a pattern whereby an apparent equilibrium is reached, whereas the thiamine in layers beyond the monolayer does not degrade.
Hospital-acquired salmonellosis traced to carmine dye capsules.
A RECENT outbreak of infection due to Salmonella cubana in 7 patients hospitalized at the University of California, San Francisco, Medical Center was traced to carmine dye ingested as a stool marker.…
The Preservation of Tablets Against Microbial Spoilage
Flore microbienne des médicaments. Données écologiques et sensibilité aux antibiotiques. 1re Partie: Formes magistrales sèches.
Microbiological contamination of medical preparations.