Microbiological and chemical dehydrogenation of withaferin A

@article{Fuska1987MicrobiologicalAC,
  title={Microbiological and chemical dehydrogenation of withaferin A},
  author={J{\'a}n Fuska and Bohumil Proksa and June Williamson and John P. N. Rosazza},
  journal={Folia Microbiologica},
  year={1987},
  volume={32},
  pages={112-115}
}
Arthrobacter simplex dehydrogenated withaferin A to 4-dehydrowithaferin A but it was not able to dehydrogenate this substrate in position 27. 27-Dehydrowithaferin A was prepared chemically using pyridinium chlorochromate. Whereas 4-dehydrowithaferin A surpassed in its effect on leukemic P388 cells the original compound and all its dérivates synthesized so far, 27-dehydrowithaferin A was biologically inactive. 

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