In this work we studied the effect of industrial pollution on the mechanisms involved in the adaptation of the nasal microbiocenosis of healthy residents of the industrial city to external influences. In the given biotop composition of the microbiota and its biological properties, as well as the specific indicators of rhinocytogram and expression of TLR-2 and TLR-4 cells of the mucous membranes have been studied. Accommodation in relatively polluted industrial areas of the city induces an increase in the population of coagulase positive staphylococci and improve their adhesion activity, as well as strengthens destructive processes in the epithelium. Analysis of resistance phenotypes of staphylococcus showed that around 30 % of the strains of coagulase negative staphylococci and about 20 % of the strains of coagulase positive staphylococci have phenotype mecA. Among coagulase negative staphylococci higher number of strains with multiple resistance to β- lactams, aminoglycosides, and antibiotics of MLS group have been revealed. To such changes in the components of microbiocenosis the cells of the mucous membrane of the nose react by increasing the numbers of TLR-2+ epithelial cells, increased expression of TLR-2 by epithelial cells and reduced expression of TLR-4 by neutrophils.