Microbicide safety/efficacy studies in animals: macaques and small animal models.

@article{Veazey2008MicrobicideSS,
  title={Microbicide safety/efficacy studies in animals: macaques and small animal models.},
  author={Ronald S Veazey},
  journal={Current opinion in HIV and AIDS},
  year={2008},
  volume={3 5},
  pages={567-73}
}
PURPOSE OF REVIEW A number of microbicide candidates have failed to prevent HIV transmission in human clinical trials, and there is uncertainty as to how many additional trials can be supported by the field. Regardless, there are far too many microbicide candidates in development, and a logical and consistent method for screening and selecting candidates for human clinical trials is desperately needed. The unique host and cell specificity of HIV, however, provides challenges for microbicide… CONTINUE READING