Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation.

@article{Zheng2008MicrobicidalPP,
  title={Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation.},
  author={Yan Zheng and François Niyonsaba and Hiroko Ushio and Shigaku Ikeda and Isao Nagaoka and Ko Okumura and Hideoki Ogawa},
  journal={Immunology},
  year={2008},
  volume={124 3},
  pages={357-67}
}
As effector cells in host defence, neutrophils actively destroy invading microorganisms via a potent antimicrobial arsenal composed of oxidants and antimicrobial peptides. Psoriasin, an Escherichia coli-cidal antimicrobial protein, has been found to be overexpressed in psoriasis, a skin disease characterized by infiltration of neutrophils. In addition to its microbicidal activities and chemotaxis of neutrophils reported previously, we hypothesized that psoriasin might regulate other neutrophil… CONTINUE READING
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