Microbial transformation of hydrocortisone by Acremonium strictum PTCC 5282.

@article{Faramarzi2002MicrobialTO,
  title={Microbial transformation of hydrocortisone by Acremonium strictum PTCC 5282.},
  author={Mohammad Faramarzi and Mojtaba Tabatabaei Yazdi and Abbas Shafiee and Gholamreza Zarrini},
  journal={Steroids},
  year={2002},
  volume={67 10},
  pages={869-72}
}
The ability of a genus of cephalosporium-like fungus isolated from soil, Acremonium strictum PTCC 5282, for hydrocortisone biotransformation has been investigated. This potential had not been previously examined. The fermentation yielded 11beta,17beta-dihydroxyandrost-4-en-3-one, 11beta,17alpha,20beta,21-tetrahydroxypregn-4-en-3-one and 21-acetoxy-11beta,17alpha,20-trihydroxypregn-4-en-3-one. Each microbial metabolite was purified and characterized using spectroscopic methods.