Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger

@article{Parshikov2005MicrobialTO,
  title={Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger},
  author={I. Parshikov and Brushapathy Miriyala and K. M. Muraleedharan and M. Avery and J. Williamson},
  journal={Journal of Industrial Microbiology and Biotechnology},
  year={2005},
  volume={33},
  pages={349-352}
}
Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated. Cultures were grown in sucrose/malt broth with artemisinin for 14 days and extracted with ethyl acetate. Extracts were characterized by liquid chromatography. Two metabolites from each fungal extract were isolated and identified using mass spectrometry and nuclear magnetic resonance. 5β-hydroxyartemisinin and 7β-hydroxyartemisinin were isolated in 63 and 32% yields… Expand
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