Microbial species delineation using whole genome sequences

@inproceedings{Varghese2015MicrobialSD,
  title={Microbial species delineation using whole genome sequences},
  author={Neha J. Varghese and Supratim Mukherjee and Natalia N Ivanova and Konstantinos T. Konstantinidis and Konstantinos Mavrommatis and Nikos C Kyrpides and Amrita Pati},
  booktitle={Nucleic acids research},
  year={2015}
}
Increased sequencing of microbial genomes has revealed that prevailing prokaryotic species assignments can be inconsistent with whole genome information for a significant number of species. The long-standing need for a systematic and scalable species assignment technique can be met by the genome-wide Average Nucleotide Identity (gANI) metric, which is widely acknowledged as a robust measure of genomic relatedness. In this work, we demonstrate that the combination of gANI and the alignment… CONTINUE READING

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