Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.

@article{Natarajan2016MicrobialSC,
  title={Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.},
  author={Niranjana Natarajan and Daijiro Hori and Sheila Flavahan and Jochen Steppan and Nicholas A Flavahan and Dan E. Berkowitz and Jennifer L Pluznick},
  journal={Physiological genomics},
  year={2016},
  volume={48 11},
  pages={
          826-834
        }
}
Short chain fatty acid (SCFA) metabolites are byproducts of gut microbial metabolism that are known to affect host physiology via host G protein-coupled receptor (GPCRs). We previously showed that an acute SCFA bolus decreases blood pressure (BP) in anesthetized mice, an effect mediated primarily via Gpr41. In this study, our aims were to identify the cellular localization of Gpr41 and to determine its role in BP regulation. We localized Gpr41 to the vascular endothelium using RT-PCR: Gpr41 is… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 8 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

The Role of Gut Microbiota in Atherosclerosis and Hypertension

Front. Pharmacol. • 2018
View 7 Excerpts
Highly Influenced

FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2018

Identifying the localization and exploring a functional role for Gprc5c in the kidney.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2018

Similar Papers

Loading similar papers…