Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering.

@article{Edwards2002MicrobialRV,
  title={Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering.},
  author={Alexander D Edwards and Shivanthi P. Manickasingham and Roman Sp{\"o}rri and Sandra S. Diebold and Oliver Schulz and Alan Sher and Tsuneyasu Kaisho and S Yukimatu Akira and Caetano Reis e Sousa},
  journal={Journal of immunology},
  year={2002},
  volume={169 7},
  pages={
          3652-60
        }
}
Dendritic cells (DC) can produce Th-polarizing cytokines and direct the class of the adaptive immune response. Microbial stimuli, cytokines, chemokines, and T cell-derived signals all have been shown to trigger cytokine synthesis by DC, but it remains unclear whether these signals are functionally equivalent and whether they determine the nature of the cytokine produced or simply initiate a preprogrammed pattern of cytokine production, which may be DC subtype specific. Here, we demonstrate that… CONTINUE READING

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Differential roles of TLR 2 and TLR 4 in recognition of Gram - negative and Gram - positive bacterial cell wall components

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