Microbial products and cytokines in sleep and fever regulation.

  title={Microbial products and cytokines in sleep and fever regulation.},
  author={James M. Krueger and Jeannie A Majde},
  journal={Critical reviews in immunology},
  volume={14 3-4},
Excessive sleepiness and fever are constitutional symptoms associated with systemic infection. Although fevers have been investigated for many years, sleep responses to infectious challenge have only recently been investigated. Inoculation of animals with bacterial, viral, protozoan and fungal organisms result in complex sleep responses dependent upon the microbial agent and route of administration. The general pattern is characterized by an initial robust increase in non-rapid eye movement… CONTINUE READING
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