Microbial production of vitamin B12: a review and future perspectives

@inproceedings{Fang2017MicrobialPO,
  title={Microbial production of vitamin B12: a review and future perspectives},
  author={Huan Fang and Jie Kang and Dawei Zhang},
  booktitle={Microbial cell factories},
  year={2017}
}
Vitamin B12 is an essential vitamin that is widely used in medical and food industries. Vitamin B12 biosynthesis is confined to few bacteria and archaea, and as such its production relies on microbial fermentation. Rational strain engineering is dependent on efficient genetic tools and a detailed knowledge of metabolic pathways, regulation of which can be applied to improve product yield. Recent advances in synthetic biology and metabolic engineering have been used to efficiently construct many… CONTINUE READING
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