Microbial production of fatty-acid-derived fuels and chemicals from plant biomass

@article{Steen2010MicrobialPO,
  title={Microbial production of fatty-acid-derived fuels and chemicals from plant biomass},
  author={Eric J. Steen and Yisheng Kang and Gregory Bokinsky and Zhihao Hu and Andreas Schirmer and Amy McClure and Stephen B. del Cardayr{\'e} and Jay D. Keasling},
  journal={Nature},
  year={2010},
  volume={463},
  pages={559-562}
}
Increasing energy costs and environmental concerns have emphasized the need to produce sustainable renewable fuels and chemicals. Major efforts to this end are focused on the microbial production of high-energy fuels by cost-effective ‘consolidated bioprocesses’. Fatty acids are composed of long alkyl chains and represent nature’s ‘petroleum’, being a primary metabolite used by cells for both chemical and energy storage functions. These energy-rich molecules are today isolated from plant and… 
Microbial engineering to produce fatty alcohols and alkanes.
TLDR
The present review aims to address the roadblocks impeding the heterologous production, the engineering pathway strategies implemented across the range of microbes in a detailed manner, and the commercial readiness of these molecules of immense application.
Biosynthesis of Fatty Alcohols in Engineered Microbial Cell Factories: Advances and Limitations
TLDR
The primary focus is on work performed in the model microorganisms, Escherichia coli and Saccharomyces cerevisiae but advances made with cyanobacteria and oleaginous yeasts are also considered.
Metabolic engineering of yeast to produce fatty acid-derived biofuels: bottlenecks and solutions
TLDR
Recent publications on metabolic engineering of yeast strains to improve the production of fatty acid-derived biofuels are summarized and the bottlenecks that limit the productivity of bio Fuels are identified.
Production of Fatty Acid-Derived Valuable Chemicals in Synthetic Microbes
TLDR
It is concluded that synthetic biology provides useful metabolic engineering strategies for economically viable production of fatty acid-derived valuable chemicals in engineered microbes.
Trends and challenges in the microbial production of lignocellulosic bioalcohol fuels
TLDR
In this review, the properties of various microorganisms, bacteria and yeasts, as well as current research efforts to develop a reliable lignocellulosic bioalcohol producing organism are compared.
Engineering Saccharomyces cerevisiae cells for production of fatty acid-derived biofuels and chemicals
TLDR
The recent strategies applied to metabolic engineering of S. cerevisiae for the production of fatty acid-derived biofuels and for improvement of the titre, rate and yield (TRY) are reviewed.
...
...

References

SHOWING 1-10 OF 33 REFERENCES
Microdiesel: Escherichia coli engineered for fuel production.
TLDR
Biodiesel-adequate FAEEs are established, referred to as Microdiesel, in metabolically engineered Escherichia coli by employing engineered micro-organisms, enabling a broader use of biodiesel-like fuels in the future.
Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
TLDR
This strategy uses the host’s highly active amino acid biosynthetic pathway and diverts its 2-keto acid intermediates for alcohol synthesis to achieve high-yield, high-specificity production of isobutanol from glucose.
New microbial fuels: a biotech perspective.
Biofuel alternatives to ethanol: pumping the microbial well.
Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels.
TLDR
Transportation biofuels such as synfuel hydrocarbons or cellulosic ethanol, if produced from low-input biomass grown on agriculturally marginal land or from waste biomass, could provide much greater supplies and environmental benefits than food-basedBiofuels.
Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol
TLDR
Saccharomyces cerevisiae was engineered with an n-butanol biosynthetic pathway, in which isozymes from a number of different organisms were substituted for Clostridial enzymes and their effect on n- butanol production was compared.
Consolidated bioprocessing of cellulosic biomass: an update.
“Designer” Biodiesel: Optimizing Fatty Ester Composition to Improve Fuel Properties†
Biodiesel is a domestic and renewable alternative with the potential to replace some of the petrodiesel market. It is obtained from vegetable oils, animal fats, or other sources with a significant
Mammalian Wax Biosynthesis
TLDR
The data suggest that fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids.
...
...