Microbial process for preparation of glucuronides of raloxifene

  title={Microbial process for preparation of glucuronides of raloxifene},
  author={Barbara S. Briggs and Patrick J Baker and Matthew D Belvo and Tessa D. Black and B G Getman and Carol A. Kemp and William L. Muth and Thomas J. Perun and Richard J. Strobel and Jonathan W. Paschal and Milton J. Zmijewski},
  journal={Journal of Industrial Microbiology and Biotechnology},
Raloxifene, also known as Evista®, has recently been approved for the prevention of osteoporosis. Three glucuronidated compounds: raloxifene-6-glucuronide, raloxifene-27-glucuronide, and raloxifene-6,27-diglucuronide are known metabolites of raloxifene in man. Reference standards of the three glucuronides were needed for clinical trials. Although chemical routes exist to make the two mono-glucuronides, these routes were unable to provide material to meet the needs of clinical trial standards… CONTINUE READING
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