Microbial pharmacodynamics of piperacillin in neutropenic mice of systematic infection due toPseudomonas aeruginosa

@article{Zhi1988MicrobialPO,
  title={Microbial pharmacodynamics of piperacillin in neutropenic mice of systematic infection due toPseudomonas aeruginosa},
  author={Jianguo Zhi and Charles H. Nightingale and Richard Quintiliani},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1988},
  volume={16},
  pages={355-375}
}
Mathematical solutions for two possible pharmacodynamic interactions (linear nonsaturable and nonlinear saturable) between antibiotics and microorganisms derived from the incorporation of clinically relevant antibiotic dosage regimens such as single bolus dosing, multiple doses, and constant infusion at steady state have been obtained. It is concluded that the saturable nonlinear interaction model between the tested antibiotic and microorganism appears appropriate. The model and its derived… CONTINUE READING
BETA
Highly Cited
This paper has 54 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS, ESTIMATED 48% COVERAGE

55 Citations

0510'97'02'08'14
Citations per Year
Semantic Scholar estimates that this publication has 55 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

Pharmacodynamic modeling of antimicrobial activity: piperacillin versus Pseudomonas aeruginosa

  • J. Zhi
  • Ph.D. dissertation, University of Connecticut,
  • 1987
Highly Influential
4 Excerpts

dose-time-response relationships for phase-nonspecific agents

  • W. J. Jusko. Pharmacodynamics of chemotherapeutic effects
  • J. Pharm. Sci. 60:892-895
  • 1971
Highly Influential
6 Excerpts

application of d-tubocurarine

  • L. B. Sheiner, D. R. Stanski, S. Vozeh, R. Miller, J. Ham. Simultaneous modeling of pharamacokinetics, pharmacodynamics
  • Clin. PharmacoL Ther. 25:358-371
  • 1979
Highly Influential
4 Excerpts

Comparison of antibiotic dosage regimens using pharmacokinetic and microbiological factors

  • G. E. Schumacher
  • Clin. Pharm
  • 1987
1 Excerpt

Similar Papers

Loading similar papers…