Microbial metalloproteomes are largely uncharacterized

  title={Microbial metalloproteomes are largely uncharacterized},
  author={Aleksandar Cvetkovic and Angeli L. Menon and Michael P. Thorgersen and Joseph W. Scott and Farris L. Poole and Francis E. Jenney and W. Andrew Lancaster and Jeremy L. Praissman and Saratchandra Shanmukh and Brian J. Vaccaro and Sunia A. Trauger and Ewa Kalisiak and Junefredo V. Apon and Gary Siuzdak and Steven M. Yannone and John A. Tainer and Michael W. W. Adams},
Metal ion cofactors afford proteins virtually unlimited catalytic potential, enable electron transfer reactions and have a great impact on protein stability. Consequently, metalloproteins have key roles in most biological processes, including respiration (iron and copper), photosynthesis (manganese) and drug metabolism (iron). Yet, predicting from genome sequence the numbers and types of metal an organism assimilates from its environment or uses in its metalloproteome is currently impossible… CONTINUE READING
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