Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84.

@article{Yun1994MicrobialMW,
  title={Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84.},
  author={B. Yun and T. Hidaka and K. Furihata and H. Seto},
  journal={The Journal of antibiotics},
  year={1994},
  volume={47 9},
  pages={
          969-75
        }
}
Geninthiocin was isolated from the mycelium of Streptomyces sp. DD84 as a tipA promoter inducing substance. Based on various NMR studies, its structure was established as a thiopeptide with oxazole and thiazole moieties, and several unusual amino acids. 
THE JOURNAL OF ANTIBIOTICS MICROBIAL METABOLITES WITH tipA PROMOTER INDUCING ACTIVITY III. THIOXAMYCIN AND ITS NOVEL DERIVATIVE, THIOACTIN, TWO THIOPEPTIDES PRODUCED BY Streptomyces sp. DP94t
Several members of the thiopeptide antibiotics such as thiostrepton, nosiheptide, micrococcin, sulfomycin and berninamycin induce expression of numerous genes of unknownfunction in StreptomycesExpand
Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19
TLDR
Compound 1 exhibited potent activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis, Mycobacterium smegmatis, and Micrococcus luteus, as well as cytotoxicity against A549 human lung carcinoma cells with an IC50 value of 6 nM. Expand
Geninthiocins C and D from Streptomyces as 35-membered macrocyclic thiopeptides with modified tail moiety
TLDR
Two new congeners of geninthiocin are reported from Streptomyces sp. Expand
Thiopeptide Antibiotics: Retrospective and Recent Advances
TLDR
Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential. Expand
Design of a novel mammalian screening system for the detection of bioavailable, non-cytotoxic streptogramin antibiotics.
TLDR
This CHO cell-based technology was more sensitive in detecting the production of the model streptogramin pristinamycin, from Streptomyces pristinaespiralis, than antibiogram tests using a variety of human pathogenic bacteria as indicator strains. Expand
α,β-Dehydroamino acids in naturally occurring peptides
TLDR
The collected data show the relation between the structure and bioactivity of α,β-dehydroamino acids and allows the activity of compounds, which were not studied in this field but which belong to a larger peptide family to be predicted. Expand
Natural thiopeptides as a privileged scaffold for drug discovery and therapeutic development
Since the start of the 21st century, antibiotic drug discovery and development from natural products has experienced a certain renaissance. Currently, basic scientific research in chemistry andExpand
Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance system
TLDR
The discovery that the structural antibiotic motifs essential for binding to TipA and to the ribosome are identical makes the multidrug recognition mechanism of TipA a useful model for ribosomal thiopeptide binding and current antibiotic drug development. Expand

References

MICROBIAL METABOLITES WITH tip A PROMOTER INDUCING ACTIVITY
Geninthiocin was isolated from the mycelium of Streptomyces sp. DD84 as a tip A promoter inducing substance. Based on various NMR studies, its structure was established as a thiopeptide with oxazoleExpand