Microbial laboratory evolution in the era of genome-scale science

@inproceedings{Conrad2011MicrobialLE,
  title={Microbial laboratory evolution in the era of genome-scale science},
  author={Tom M. Conrad and Nathan E. Lewis and Bernhard {\O}. Palsson},
  booktitle={Molecular systems biology},
  year={2011}
}
Laboratory evolution studies provide fundamental biological insight through direct observation of the evolution process. They not only enable testing of evolutionary theory and principles, but also have applications to metabolic engineering and human health. Genome-scale tools are revolutionizing studies of laboratory evolution by providing complete determination of the genetic basis of adaptation and the changes in the organism's gene expression state. Here, we review studies centered on four… CONTINUE READING
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