Microbial-gut interactions in health and disease. Immune responses.

  title={Microbial-gut interactions in health and disease. Immune responses.},
  author={Karen M. Pickard and Alan Ronald Bremner and John N. Gordon and Thomas Macdonald},
  journal={Best practice & research. Clinical gastroenterology},
  volume={18 2},
The indigenous bacterial microflora colonize the gut at birth and remain there throughout life. Approximately 10(14) bacteria are present in the ileum and colon and they are clearly immunogenic. The evidence is strong that the vast majority of IgA plasma cells in normal human gut are responding to the antigens of the flora, and although the flora is also responsible for producing the large numbers of T cells which are present in the gut of healthy individuals, the types of T cell response which… CONTINUE READING