Microbial glycolipids: possible virulence factors that scavenge oxygen radicals.

  title={Microbial glycolipids: possible virulence factors that scavenge oxygen radicals.},
  author={John Chan and Toru Fujiwara and Patrick Brennan and Michael McNeil and Salvatore Joseph Turco and J C Sibille and Marc L. Snapper and Philip Aisen and Barry R. Bloom},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 7},
Two important pathogens of developing countries, Mycobacterium leprae, the etiologic agent of leprosy, and Leishmania donovani, the protozoal parasite that causes kalaazar, persist in the human host primarily in mononuclear phagocytes. The mechanisms by which they survive in these otherwise highly cytocidal cells are presently unknown. Since the best understood cytocidal mechanism of these cells is the oxygen-dependent system that provides lethal oxidants including the superoxide anion (O2… CONTINUE READING
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